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KMID : 1098420080160050326
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Korean Journal of Medicinal Crop Science
2008 Volume.16 No. 5 p.326 ~ p.331
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Extracts of Artemisia princeps Pampanini Inhibit Lipopolysaccharide-induced Nitric Oxide, Cyclooxygenase-2, Prostaglandin E2, and Tumor Necrosis Factor-α Production from Murine Macrophage RAW 264.7 Cells
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Yun Jun-Yong
Choi Se-Yong
Park Pyo-Jam
Chung Hae-Gon
Shin Heung-Mook
Suk Kyoung-Ho
Lim Beong-Ou
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Abstract
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To search for immunoactive natural products exerting anti-inflammatory activity, we have evaluated the effects on the water extracts of Artemisia princeps Pampanini (APP) on lipopolysaccharide-induced nitric oxide (NO), tumor necrosis factor- (TNF-), and prostaglandin () production by RAW 264.7 macrophage cell line. Our data indicate that this extract is a potent inhibitor of NO production and it also significantly decreased PGE2 and TNF- production. Consistent with these results, the protein and mRNA expression level of inducible NO synthase (iNOS) and cyclooxygenase-2 (COX-2) was inhibited by water extracts of APP in a dose-dependent manner. These results suggest that APP may exert anti-inflammatory and analgesic effects possibly by suppressing the inducible NO synthase and COX-2 expressions.
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KEYWORD
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Artemisia princeps Pampanini, Nitric Oxide
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